Rapid re-emergence of YMDD mutation of hepatitis B virus with hepatic decompensation after lamivudine retreatment

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hepatitis b virus ymdd-motif mutations with emergence of lamivudine-resistant mutants: a threat to recovery

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Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.

Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact YMDD motif, which included an amino acid substitution, rtA181T, in the reverse...

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Clinical characteristics of asymptomatic hepatitis B virus carriers with YMDD mutant not treated with lamivudine.

We previously developed a method of detecting drug-resistant mutation of hepatitis B virus (tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) mutation) caused by the antiviral agent lamivudine. Using this method, we also reported that YMDD mutation is present in asymptomatic carriers that had not been administered antiviral agents. Thus, we investigated the clinical charact...

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Rate of YMDD motif mutants in lamivudine-untreated Iranian patients with chronic hepatitis B virus infection.

BACKGROUND Lamivudine is used for the treatment of chronic hepatitis B patients. Recent studies show that the YMDD motif mutants (resistant hepatitis B virus) occur as natural genome variability in lamivudine-untreated chronic hepatitis B patients. In this study we aimed to determine the rate of YMDD motif mutants in lamivudine-untreated chronic hepatitis B patients in Iran. PATIENTS AND METH...

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2008

ISSN: 1007-9327

DOI: 10.3748/wjg.14.4416